溶解性 易溶于氯仿，溶于甲醇、乙醇，微溶于水
存貯條件 儲存溫度2-8℃
描述
別名 (-)-石杉堿甲;(-)-Selagine
生化機理
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease.
應(yīng)用 石杉堿甲不僅通過抑制膽堿酯酶活性，還可以通過影響自由基系統(tǒng)，降低生長抑素、細胞內(nèi)[Ca2+]、谷氨酸含量，提高鈣調(diào)蛋白(CaM)和鈣調(diào)蛋白的信使核糖核酸(CaM mRNA)表達水平等多種藥理機制，提高認知功能和學習記憶能力。