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英文名稱 Anti-BPI
中文名稱： 殺菌/通透性增強蛋白抗體
別 名 Bactericidal permeability-increasing protein; bactericidal/permeability-increasing protein; BPI; CAP 57; BPI_HUMAN.
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human
產(chǎn)品類型 一抗
研究領(lǐng)域 細胞生物 免疫學(xué) 細胞凋亡 細菌及病毒 t-淋巴細胞
蛋白分子量 predicted molecular weight: 50kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human BPI
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.
Function : The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Subunit : Monomer. Homodimer; disulfide-linked.
Subcellular Location : Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Tissue Specificity : Restricted to cells of the myeloid series.
Similarity : Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
殺菌／通透性增加蛋白(Bactericidal／permeability-increasing protein，BPI)是哺乳動物中性粒細胞中存在的一種堿性蛋白，BPI能與革蘭氏陰性菌脂多糖結(jié)合，增加外膜對抗菌藥物的通透性，具有中和內(nèi)毒素和殺滅細菌的生物學(xué)作用，在革蘭氏陰性菌感染的治療方面有良好的發(fā)展前景。
中文名稱： 殺菌/通透性增強蛋白抗體
別 名 Bactericidal permeability-increasing protein; bactericidal/permeability-increasing protein; BPI; CAP 57; BPI_HUMAN.
詳細介紹：
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human
產(chǎn)品類型 一抗
研究領(lǐng)域 細胞生物 免疫學(xué) 細胞凋亡 細菌及病毒 t-淋巴細胞
蛋白分子量 predicted molecular weight: 50kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human BPI
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關(guān)資料：
產(chǎn)品介紹 The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.
Function : The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Subunit : Monomer. Homodimer; disulfide-linked.
Subcellular Location : Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Tissue Specificity : Restricted to cells of the myeloid series.
Similarity : Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
殺菌／通透性增加蛋白(Bactericidal／permeability-increasing protein，BPI)是哺乳動物中性粒細胞中存在的一種堿性蛋白，BPI能與革蘭氏陰性菌脂多糖結(jié)合，增加外膜對抗菌藥物的通透性，具有中和內(nèi)毒素和殺滅細菌的生物學(xué)作用，在革蘭氏陰性菌感染的治療方面有良好的發(fā)展前景。
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